While the COVID-19 pandemic has caused harm in the health sectors of many cities, it has also brought to light challenges that metropolises faced in other areas. At the same time, it serves as an opportunity to rethink cities’ approaches to innovation and inclusive growth in order to move towards a more inclusive, sustainable society. During this interview with Chicago’s Mayor Ms. Lightfoot, we will talk about the initiatives that the city has taken towards fighting specific problems such as housing, education, crime, justice or demographic changes and, specifically, how the COVID-19 pandemic has affected the city and those already existing challenges.