The COVID-19 crisis has exposed and exacerbated underlying inequalities in cities, and has shown how deep inequalities make society as a whole more vulnerable as well as how fragile modern economies are. Now, cities have a key role to play in the inclusive and sustainable economic recovery as engines of growth. In the aftermath of COVID-19, leaving no one behind and reaching the most vulnerable will be fundamental for achieving an equitable and more risk-resilient society. In this context, how can we ensure a pandemic response that does not leave anybody behind? How can the economic, social and health imperatives be reconciled? What role can innovation and digital inclusion policies play here?